BRM Antibody
货号：
6889S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6889S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | BRM Antibody recognizes endogenous levels of total BRM protein. This antibody does not cross-react with BRG1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | ATP-dependent chromatin remodeling complexes play an essential role in the regulation of various nuclear processes such as gene expression, DNA replication, and repair (1, 2). The SWI/SNF chromatin remodeling complex consists of more than 10 subunits with a single molecule of the ATPase catalytic subunit BRM or BRG1, but not both. The activities of these two subunits drive the disruption of histone-DNA contacts that lead to changes in accessibility of crucial regulatory elements within chromatin (2-5). The BRM/BRG1 containing SWI/SNF complexes are recruited to target promoters by transcription factors such as nuclear receptors, p53, RB, and BRCA1 to regulate gene activation, cell growth, the cell cycle, and differentiation processes (1, 6-9). BRM and BRG1 are also considered to be tumor suppressors and their expression levels are severely reduced in several cancer cell lines (10-13). |
| 存放说明 | -20C |
| 计算分子量 | 200 |
参考图片Western blot analysis of extracts from various cell lines using BRM Antibody. 使用BRM Antibody，免疫印迹(Western blot)分析不同细胞中BRM的蛋白水平。 |
