BMPR2 Antibody
货号：
6979S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6979S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | BMPR2 Antibody recognizes endogenous levels of total BMPR2 protein. This antibody may also detect a 115 Kd unspecific band. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis (1-5). In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs (6,7). BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes (7). In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 150 |
参考图片Western blot analysis of extracts from various cell lines using BMPR2 Antibody.使用BMPR2抗体与多种细胞提取物进行western blot实验。 |
