| 货号 | 3543S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Bit1 Antibody detects endogenous levels of total human Bit1 protein. It also detects overexpressed bovine Bit1 and may detect overexpressed levels of mouse and rat Bit1. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | Bit1 is a mitochondrial protein discovered as a regulator of anoikis, a process of apoptosis triggered by the loss of cell adhesion to the extracellular matrix (1,2). Like several other mitochondrial apoptotic regulators (Cytochrome c, Smac, HtrA2, AIF, EndoG), Bit1 is released into the cytoplasm during apoptosis (1,3). Cytoplasmic Bit1 associates with the Groucho family of transcriptional regulator AES (1,4). Interaction between Bit1 and AES promotes apoptosis, and this complex is suppressed by integrin mediated cell attachment. |
| 存放说明 | -20C |
| 计算分子量 | 19, 21 |
Western blot analysis of extracts from HeLa cells mock transfected or transfected with bovine Bit1, using Bit1 Antibody. Western blot方法检测 HeLa 细胞提取物：空质粒转染（-）或小牛Bit1转染；使用抗体为Bit1 Antibody。 | |
Western blot analysis of extracts from K562, Raji, MCF7 and A204 cell lines, using Bit1 Antibody. Western blot 方法检测 K562、Raji、MCF7和A204 细胞提取物，使用抗体为Bit1 Antibody。 |
