BCL6 Antibody
货号：
4242S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4242S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | The BCL6 Antibody detects endogenous levels of BCL6. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Chromosomal translocations result in misregulation of the proto-oncogene Bcl-6 in patients with B cell-derived non-Hodgkins lymphoma (1). The Bcl-6 gene is selectively expressed in mature B cells and encodes a nuclear phosphoprotein that belongs to the BTB/POZ zinc finger family of transcription factors (2-3). Bcl-6 protein can bind to target DNA sequences of Stat6 and, analogous to Stat6, modulate the expression of interleukin-4-induced genes (4). Furthermore, Bcl-6 restrains p53-dependent senescence, making Bcl-6 active tumors functionally p53 negative (5). The mitogen-activated protein kinases, Erk1 and Erk2, but not JNK, phosphorylate Bcl-6 at multiple sites. Phosphorylation of Bcl-6 at Ser333 and Ser343 results in degradation of Bcl-6 by the ubiquitin/proteasome pathway in B cells (6-7). In addition, Bcl-6 is acetylated and its transcriptional repressor function is inhibited by the transcriptional co-activator p300 (8). |
| 存放说明 | -20C |
| 计算分子量 | 87 to 98 |
参考图片Western blot analysis of Ramos and A20 cell extracts using BCL6 Antibody.Western免疫印迹。用BCL6 Antibody研究Ramos 和 A20 的细胞提取液。 |
