BAG6 Antibody
货号：
8523S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8523S |
| 反应种属 | Human/Mouse/Rat/Monkey/Pig |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | BAG6 Antibody recognizes endogenous levels of total BAG6 protein. It does not cross-react with other BCL2-associated athanogene (Bag) family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | BAG6 (BCL2-associated athanogene-6), alternately known as BAT3 (HLA-B-associated transcript 3), was originally identified as a gene within the class III region of the human major histocompatibility complex, but has subsequently been found to exhibit protein chaperone activity. BAG6, in conjunction with other chaperone proteins and ubiquitin ligases, regulates protein stability and insertion of tail-anchored membrane proteins into the endoplasmic reticulum (1-3). The BAT3 complex, consisting of BAG6, TRC35 and Ubl4a localizes to ribosomes synthesizing membrane proteins and facilitates tailed-anchored protein capture by TRC40 and subsequent insertion of the nascent protein in to the ER membrane (4,5). BAG6 also plays a critical role in clearing cells of mis-folded and mis-localized peptides via endoplasmic reticulum-associated degradation and the ubiquitin-proteasome system (1,6,7). BAG6 may also act as a chaperone for glycoproteins through its interaction with DERLIN2 (8).
In addition to its role as a chaperone, BAG6 has also been implicated in regulating chromatin structure and gene expression. For example, BAG6 and SET1A act as binding partners for BORIS to effect changes of chromatin structure and gene expression (9). Similarly, increased expression of BAG6 induces p300-mediated acetylation of p53, which is required for DNA damage response (10). BAG6 has also been found to interact with TGF-β, and in so doing acts as a positive regulator of TGF-β1 stimulation of type 1 collagen expression (11). BAG6 also suppresses bone morphogenic protein (BMP) signaling via its interaction with and regulation of small C-terminal domain phosphatase (SCP) that dephosphorylates SMAD proteins resulting in subsequent termination of BMP-mediated events (12). |
| 存放说明 | -20C |
| 计算分子量 | 150 |
参考图片Western blot analysis of extracts from various cell lines using BAG6 Antibody. |
