BACH1/BRIP1 Antibody
货号：
4578S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4578S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | BACH1, also known as BRIP1 and FANCJ, is a DNA helicase involved in repair of DNA cross-links and double strand breaks (1-3). Interaction between phosphorylated BACH1 and BRCA1 is required for DNA damage-induced checkpoint signaling (3,4). Originally identified as a breast cancer susceptibility gene (1), the BACH1 gene is mutated in Fanconi anemia (5), a recessive disorder characterized by multiple congenital abnormalities, progressive bone marrow failure and high cancer risk/predisposition. The interaction with BRCA1 and the existence of mutations in patients with early onset breast cancer indicate that BACH1 may act as a tumor suppressor.BACH1是一种DNA解螺旋酶，也称为BRIP1或FANCJ，与DNA 交联和DNA双链断裂的修复相关(1-3)。磷酸化BACH1与BRCA1的相互作用对于DNA损伤诱导的检测点信号传导是必须的(3,4)。BACH1基因最初被认为是乳腺癌的易感基因（1），在范可尼贫血中发生突变(5)，范可尼贫血是以多发性先天畸形、进行性骨髓衰竭和高肿瘤风险/易感性。与BRCA1相互作用并且在早期乳腺癌病人中存在突变提示BACH1基因可能是一个肿瘤抑制基因。 |
| 存放说明 | -20C |
| 计算分子量 | 145 |
参考图片Western blot analysis of extracts from SH-SY5Y, Saos-2 and Jurkat cells using BACH1/BRIP1 Antibody.使用BACH1/BRIP1抗体利用western blot技术检测SH-SY5Y,Saos-2和Jurkat 细胞提取物。 |
