| 货号 | 95336S |
| 反应种属 | Human\Mouse\Rat |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | Prdx6 Antibody recognizes endogenous levels of total Prdx6 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Peroxiredoxin 6 (Prdx6) belongs to an antioxidant enzyme family of non-seleno peroxidases (prdx). It is a unique member of the Prdx family exhibiting both glutathione peroxidase and phospholipase A2 activities (1,2). Prdx6 regulates phospholipid turnover as well as protects cells against oxidative injury. Prdx6 is expressed in all major organs with a particularly high level in lung where it regulates lung surfactant phospholipid synthesis and turnover (3-5). Studies show Prdx6 is aberrantly expressed in various cancers and promotes cancer cell metastasis and invasion (6,7). Elevated expression of Prdx6 and other prdx family members contributes to drug resistance in cancer cells (8,9). Prdx6 is also expressed in neutrophils, where it regulates the function of these cells and activates NADPH oxidase (Nox2) ( 10-12). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
| 参考文献 | 1 . Kang, S.W. et al. (1998) J Biol Chem 273, 6303-11. 2 . Chen, J.W. et al. (2000) J Biol Chem 275, 28421-7. 3 . Manevich, Y. and Fisher, A.B. (2005) Free Radic Biol Med 38, 1422-32. 4 . Schremmer, B. et al. (2007) Subcell Biochem 44, 317-44. 5 . Lee, S.B. et al. (2009) Mol Cells 28, 583-8. 6 . Ho, J.N. et al. (2010) Mol Cancer Ther 9, 825-32. 7 . Yun, H.M. et al. (2014) Free Radic Biol Med 69, 367-76. 8 . Pak, J.H. et al. (2011) Cancer Invest 29, 21-8. 9 . Kalinina, E.V. et al. (2012) Bull Exp Biol Med 153, 878-81. 10 . Chatterjee, S. et al. (2011) J Biol Chem 286, 11696-706. 11 . Ambruso, D.R. et al. (2012) Biochim Biophys Acta 1823, 306-15. 12 . Ambruso, D.R. (2013) Methods Enzymol 527, 145-67. |
Western blot analysis of extracts from HeLa and MCF7 cells using Prdx6 Antibody. |
