ATP2A2/SERCA2 Antibody
货号：
4388S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4388S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | ATP2A2/SERCA2 Antibody detects endogenous levels of total ATP2A2/SERCA2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The ATP2A2 (SERCA2) calcium pump is one of several sarcoplasmic and endoplasmic reticulum Ca2+-ATPases responsible for regulating calcium transport across intracellular membranes (1). Multiple isoforms have been isolated, with ATP2A2a (SERCA2a) found predominantly in the sarcoplasmic reticulum of muscle cells and ATP2A2b (SERCA2b) more ubiquitously expressed in the endoplasmic reticulum of most cell types (2). An isoform containing a truncated carboxy region (ATP2A2c) is expressed in epithelial and hematopoietic cell lines and may be involved in monocyte differentiation (3). Post-translational modification of ATP2A2 (SERCA2), including phosphorylation and tyrosine nitration, modify Ca2+ -ATPase activity and calcium transport (4,5). Mutation in the corresponding ATP2A2 (SERCA2) gene results in Darier disease, a skin disorder characterized by the presence of dark, keratotic papules or rash found on the head and torso (6). |
| 存放说明 | -20C |
| 计算分子量 | 114, 140 |
参考图片Western blot analysis of extracts from various cell types using ATP2A2/SERCA2 Antibody.对多个细胞系使用ATP2A2/SERCA2抗体进行Western blot分析。 |
