Ataxin-1 Antibody
货号：
2177S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2177S |
| 反应种属 | Human/Mouse/Rat/D.melanogaster |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Ataxin-1 Antibody detects endogenous levels of total ataxin-1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Spinocerebellar ataxia 1 (SCA1), an autosomal dominant neurodegenerative disorder, is characterized by slurred speech, loss of limb coordination, and gait abnormalities resulting from the degeneration of cerebellar Purkinje cells and of a subset of brainstem neurons (1). Individuals with SCA1 have a highly polymorphic CAG repeat expansion encoding a polyglutamine tract in ataxin-1 (2). Akt phosphorylates ataxin-1 at Ser776, which regulates an association with 14-3-3. This interaction increases ataxin-1 stabilization and accumulation resulting in enhanced neurodegeneration (3). In addition, HSP70 controls the effect that phosphorylation has on ataxin-1 stability (4). |
| 存放说明 | -20C |
| 计算分子量 | 105 |
参考图片Western blot analysis of extracts from rat and mouse brain using Ataxin-1 Antibody. Western blot分析大鼠和小鼠大脑提取物，使用的抗体是Ataxin-1 Antibody 兔多抗。 |
