Arrestin 1/S-Arrestin Antibody
货号：
11828S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11828S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Arrestin 1/S-Arrestin Antibody recognizes endogenous levels of total Arrestin 1/S-Arrestin protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (β-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). β-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways (3,4). β-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that β-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9,10). Arrestin 1/S-Arrestin inactivates rhodopsin-mediated signaling through binding to the light-activated phosphorylated rod photoreceptor, thereby preventing coupling to transducin, rhodopsins cognate G protein (11). Research studies have proposed that mutations in the Arrestin 1/S-Arrestin gene are linked to Oguchi disease (12,13) and Retinitis Pigmentosa (14). |
| 存放说明 | -20C |
| 计算分子量 | 52 |
参考图片Western blot analysis of extracts from various tissues using Arrestin 1/S-Arrestin Antibody. As expected, Arrestin 1/S-Arrestin was not detected in kidney extract. Western blot 检测多种组织提取物，使用的抗体是Arrestin 1/S-Arrestin Antibody兔多抗。如预期，Arrestin 1/S-Arrestin 未在肾脏提取物中被检出。 |
