AQP2 Antibody
货号：
3487S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3487S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | AQP2 Antibody detects endogenous levels of total AQP2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Aquaporin 2 (AQP2) is a water transport protein that forms water channels in kidney tubules and plays a predominant role in controlling organism water homeostasis (1). Members of the aquaporin family are multiple pass transmembrane proteins that form homotetramers to facilitate the flow of water across the plasma membrane. At least thirteen aquaporins have been indentified to date (AQP0 through AQP12) and together this family of small, hydrophobic proteins plays a role in an array of biological processes that include urine formation, cell motility, fertilization, cell junction formation and regulation of overall water homeostasis (2). AQP2 tetramers form water channels that facilitate water transport and excretion in the kidney (3). This transport protein is localized to the plasma membrane is response to endocrine signaling. Posterior pituitary hormones arginine vasopressin (AVP) and ADH regulate osmotic water cell permeability by triggering phosphorylation and subsequent exocytosis of AQP2 (1,4). Mutations in the corresponding AQP2 gene cause a rare form of diabetes known as nephrogenic diabetes insipidus. This autosomal dominant disorder is characterized by abnormal water reabsorption by kidney tubules due, in part, to either nonfunctional or mislocalized AQP2 protein (5). |
| 存放说明 | -20C |
| 计算分子量 | 26 |
参考图片Western blot analysis of extracts from various cell lines using AQP2 Antibody. Wetern blot检测多种细胞提取物，所用抗体为AQP2 Antibody。 |
