| 货号 | 2509S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-IC |
| 目标/特异性 | AP-2β Antibody detects endogenous levels of total AP-2β protein. |
| 使用方法 | WB(1:1000) IP (1:100) IF-IC (1:100) |
| 供应商 | CST |
| 背景 | The sequence-specific transcription factor activator protein 2β (AP-2β) is required for normal kidney development (1). AP-2β knockout mice die 1-2 days after birth due to polycystic kidney disease (1). Massive apoptosis occured during kidney deveopment at the end of embryogenesis in these mice (1). Overexpressed AP-2β has been to found to suppress c-myc-induced apoptosis, indicating a role of this transcription factor in cell survival (1). In addition, overexpression of AP-2β is shown to be related to impaired insulin signaling in adipocytes, and is therefore proposed to be a candidate gene that may relate to obesity (2). |
| 存放说明 | -20C |
| 计算分子量 | 49 |
Confocal immunofluorescent analysis of SH-SY5Y cells labeled with AP-2β Antibody (green, left) compared to a nonspecific negative control antibody (right). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). 共聚焦免疫荧光分析SH-SY5Y 细胞 (绿色，左图)，所用抗体为AP-2β Antibody与非特异性阴性对照抗体(右图)。肌动蛋白微丝用Alexa Fluor® 555 phalloidin(红色)标记。 | |
