Annexin A7 Antibody
货号：
3666S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3666S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Annexin A7 Antibody detects endogenous levels of total annexin A7 protein, including isoforms 1 and 2. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Annexin A7/ANXA7 is a member of the annexin family of calcium/phospholipid-binding proteins, and is involved in the process of membrane fusion and exocytosis (1). Annexin A7 is a GTPase, and both GTP-binding and PKC activity are important in regulating protein function (2,3). Membrane binding of annexin A7 is calcium dependent (4). Two isoforms exist due to alternative splicing. Subcellular localization of annexin A7 has been shown to be in the cytoplasm, vesicular structures, membrane and in adrenal chromaffin granules (5,6). Nuclear localization has been shown in the developing mouse central nervous system as well as in adult mouse brain (7). Annexin A7-deficient mouse studies show that the protein has a role in insulin secretion and calcium signaling (8) as well as cardiac intracellular calcium homeostasis electrical stability (9). The gene for annexin A7 is a putative tumor suppressor (10), and alterations in the copy number have been reported in prostate cancer (11). Annexin A7 expression has also been correlated with survival in human glioblastoma patients (12), and haploinsufficiency in mice may promote genetic instability leading to tumorigenesis (13). |
| 存放说明 | -20C |
| 计算分子量 | 47, 51 |
参考图片Western blot analysis of extracts from U251, SHSY-5Y and COS cells using Annexin A7 Antibody. 对U251, SHSY-5Y和COS细胞裂解液使用Annexin A7抗体进行Western blot分析。 |
