Annexin A1 Antibody
货号：
3299S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3299S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Annexin A1 Antibody detects endogenous levels of total annexin A1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology (1). Annexin-1 (ANXA1) is the first characterized member of the annexin family of proteins able to bind to cellular membranes in a calcium-dependent manner which promotes membrane fusion and is involved in endocytosis (2-4). Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity (5,6). Annexin A1 can accumulate on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation (7). Phosphorylation by PKC, EGFR and Chak1 results in inhibition of annexin A1 function (8-10). Annexin A1 has also been identified as one of the eat-me signals on apoptotic cells to be recognised and ingested by phagocytes (11). Annexin A1, as an endogenous anti-inflammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development (12-14). |
| 存放说明 | -20C |
| 计算分子量 | 37 |
参考图片Western blot analysis of extracts from various cell lines using Annexin A1 Antibody. 对多个细胞系使用Annexin A1抗体进行Western blot分析。 |
