ADAP Antibody
货号：
11957S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11957S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ADAP Antibody recognizes endogenous levels of total ADAP protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | ADAP (adhesion and degranulation-promoting adaptor protein/SLAP-130/Fyb) is an SH3 domain-containing adaptor protein expressed by T cells, NK cells, and myeloid cells (1,2). There are two isoforms of ADAP with predicted molecular weights of 85 kDa and 90 kDa, but observed molecular weights of 120 kDa and 130 kDa (1-3). ADAP was identified as an adaptor protein that interacts with SLP-76 following T cell receptor (TCR) stimulation and was subsequently found to be important for several aspects of T cell activation (1,2). For example, ADAP is required for integrin-dependent clustering, signaling, and adhesion (4,5). In addition, ADAP interacts with CARMA1 and facilitates assembly of the CARMA1-Bcl10-MALT1 complex important for NF-κB activation downstream of TCR activation (6). Finally, following binding of a T cell to an antigen presenting cell, ADAP forms a ring at the immunological synapse that recruits dynein to enable microtubule-organizing center polarization (7). |
| 存放说明 | -20C |
| 计算分子量 | 120, 130 |
参考图片Western blot analysis of extracts from NK-92, MOLT-4, and Raw 264.7 cells using ADAP Antibody.Western blot分析NK-92，MOLT-4和Raw 264.7细胞的提取物，使用的抗体是：ADAP Antibody。 |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human ADAP (hADAP-Myc/DDK; +), using ADAP Antibody.Western blot分析293T细胞的提取物，对照转染(-)或用Myc/DDK标记的全长的人ADAP (hADAP-Myc/DDK; +)转染。使用的抗体是：ADAP Antibody。 |
