ACVR1 Antibody
货号：
4398S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4398S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ACVR1 Antibody detects endogenous levels of total ACVR1 protein. The antibody also cross-reacts with 35 kDa and 95 kDa bands of unknown origin. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The activin A receptor type 1 (ACVR1) is a membrane associated serine/threonine kinase receptor that binds activin A and related TGF-β superfamily growth factors, including bone morphogenetic protein 2 (BMP2) and BMP4, 6 and 7 (1-3). Functional activin receptors are composed of a pair of type I and type II activin receptor proteins. Following ligand binding, ACVR1 is phosphorylated by its type II binding partner, which allows recruitment and activation of receptor regulated SMAD (R-Smad) proteins (4). Phosphorylation of R-Smad proteins results in their translocation to the nucleus where R-Smads stimulate transcription of target genes (5). Mutations in the corresponding ACVR1 gene are associated with the genetic developmental disorders hereditary hemorrhagic telangiectasia and fibrodysplasia ossificans progressive (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 57 |
参考图片Western blot analysis of extracts from various cell lines using ACVR1 Antibody.使用ACVR1对多种细胞提取物进行western blot分析。 |
