ACF1 Antibody
货号：
6255S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6255S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ACF1 Antibody recognizes endogenous levels of total ACF1 protein (isoforms 1 and 2). |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The mammalian imitation SWI (ISWI) complexes are characterized by two ATPase subunits: Snf2h and Snf2l (1). Snf2h interacts with ATP-utilizing chromatin assembly and remodeling factor 1 (ACF1) to comprise the ACF chromatin-remodeling complex (1). ACF1 (BAZ1A) has distinct roles in development (2), regulation of chromatin structure (3), and DNA damage response (4,5). Different developmental stages dictate the expression of ACF1 in Drosophila, and alterations in ACF1 expression during Drosophila development leads to deviation from normal chromatin organization (2). ACF1 functions in heterochromatin formation during development and is involved in the initial establishment of diversified chromatin structures. In vivo studies demonstrate that heterochromatin protein 1 (HP1) binding to methylated lysine 9 of histone H3 is enhanced by the interaction of ACF1 with chromatin (6). Chromatin-remodeling factors are required during DNA damage in order to allow signaling molecules and damaging enzymes to access the site (4). Depletion of hACF1 increases apoptosis and vulnerability to radiation and compromises G2/M arrest activated in response to X-ray and UV exposure (4). Depletion of ACF1 also sensitizes cells to DNA double-stranded breaks (DSBs) and impairs DNA repair (5). Specifically, accumulation of Ku at DSBs sites may depend on the presence of ACF1 (5). |
| 存放说明 | -20C |
| 计算分子量 | 203 |
参考图片Western blot analysis of extracts from various cell lines using ACF1 Antibody. 使用ACF1 Antibody，免疫印迹(Western blot)分析不同细胞中ACF1蛋白水平。 |
