| 货号 | 4190S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-IC |
| 目标/特异性 | Acetyl-CoA Carboxylase 1 Antibody detects endogenous levels of total acetyl-CoA carboxylase 1 protein. Immunofluorescence data indicate that the antibody is more reactive to rodent than human proteins. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265 kDa ACCα (ACC1) is the predominant isoform found in liver, adipocytes, and mammary gland, while the 280 kDa ACCβ (ACC2) is the major isoform in skeletal muscle and heart (1). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (2). ACC is a potential target of anti-obesity drugs (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 265 |
Western blot analysis of extracts from various cell types using Acetyl-CoA Carboxylase 1 Antibody. Wetern blot检测多种细胞提取物，所用抗体为Acetyl-CoA Carboxylase 1 Antibody | |
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with either SignalSilence® ACC1 siRNA or SignalSilence® ACC2 siRNA, using Acetyl-CoA Carboxylase 1 Antibody and β-Actin (13E5) Rabbit mAb #4970. Wetern blot检测hela细胞提取物，细胞空转或用SignalSilence® ACC1 siRNA 或 SignalSilence® ACC2 siRNA转染，所用抗体为Acetyl-CoA Carboxylase 1 Antibody和β-Actin (13E5) Rabbit mAb兔单抗 #4970. |
