| 货号 | 4477S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ABCG2 Antibody detects endogenous levels of total ABCG2 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells (1-6). ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. High expression of ABCG2 was found in placenta as well as cell lines selected for resistance to a number of chemotherapeutic drugs, including mitoxantrone, doxorubicin, topotecan and flavopiridol. In rodents, the highest expression of ABCG2 was found in kidney (8). ABCG2 expression has also been observed in stem cell populations, particularly in hematopoietic and neuronal stem cells and is downregulated with differentiation (9-12). |
| 存放说明 | -20C |
| 计算分子量 | 65-80 |
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with a construct overexpressing human ABCG2 (+), using ABCG2 Antibody. Wetern blot检测 COS-7提取物，细胞空转或用过表达人 ABCG2 (+)蛋白的截体转染，所用抗体为ABCG2 Antibody | |
Western blot analysis of extracts from RPMI 8226 cells using ABCG2 Antibody. Wetern blot检测RPMI 8226细胞提取物，所用抗体为ABCG2 Antibody |
