| 货号 | 17334S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | CYP17A1 Antibody recognizes endogenous levels of total CYP17A1 protein. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CYP17A1, also known as cytochrome P450C17, is a steroidogenic enzyme belonging to the P450 cytochrome superfamily of monooxygenases (1, 2). In humans, CYP17A1 expression is abundantly expressed in the adrenal cortex, where it plays a central role in the androgen synthesis pathway (2). CYP17A1 is the primary target of abiraterone, a synthetic steroid used in the treatment of castration-resistant prostate cancer (CRPC) (3, 4). Abiraterone is converted to the more active form D4A, which antagonizes androgen receptor signaling by inhibiting CYP17A1 and other steroidogenic enzymes (3, 4). This suppresses the synthesis of 5α-dihydrotestosterone (DHT), which is a driver of castration-resistant prostate cancer cell growth (3, 4). |
| 存放说明 | -20C |
| 计算分子量 | 55 |
| 参考文献 | 1 . Missaghian, E. et al. (2009) J Endocrinol 202, 99-109. 2 . Tee, M.K. and Miller, W.L. (2013) J Biol Chem 288, 23903-13. 3 . Li, Z. et al. (2015) Nature 523, 347-51. 4 . Thoma, C. (2015) Nat Rev Urol 12, 363. |
Western blot analysis of extract from human adrenal cortex using CYP17A1 Antibody. |
