| 货号 | 70081S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | HO-1 Antibody recognizes endogenous levels of total HO-1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme that results in the release of carbon monoxide, iron, and biliverdin (1). The products of this enzymatic reaction play important biological roles in antioxidant, anti-inflammatory and cytoprotective functions (2). Heme oxygenase comprises two isozymes, including the constitutively expressed HO-2 isozyme and the inducible HO-1 isozyme (3). Inducible HO-1 is expressed as an adaptive response to several stimuli, including heme, metals, and hormones (4). The induction of HO-1 has been implicated in numerous disease states, such as transplant rejection, hypertension, atherosclerosis, Alzheimer disease, endotoxic shock, diabetes, inflammation, and neurological disorders (1,5). |
| 存放说明 | -20C |
| 计算分子量 | 28 |
| 参考文献 | 1 . Abraham, N.G. and Kappas, A. (2008) Pharmacol Rev 60, 79-127. 2 . Otterbein, L.E. et al. (2003) Trends Immunol 24, 449-55. 3 . Cruse, I. and Maines, M.D. (1988) J Biol Chem 263, 3348-53. 4 . Maines, M.D. (1988) FASEB J 2, 2557-68. 5 . Schipper, H.M. et al. (2009) Curr Alzheimer Res 6, 424-30. |
Western blot analysis of extracts from HeLa untreated or treated with arsenite (50 μM for 8 hr), and 3T3 cells using HO-1 Antibody (upper), or beta-Actin (13E5) Rabbit mAb. |
