| 货号 | 3775T |
| 反应种属 | Human, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | Jak3 Antibody detects endogenous levels of total Jak3 protein. No cross-reactivity was detected with other family members at physiological conditions. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4) and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. |
| 运输条件 | 1 |
| 存放说明 | -20C |
| 计算分子量 | 115 |
| 参考文献 | 1 . Leonard, W.J. and OShea, J.J. (1998) Annu Rev Immunol 16, 293-322. 2 . Darnell, J.E. (1997) Science 277, 1630-5. 3 . VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93. 4 . Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92. 5 . Zhu, T. et al. (1998) J Biol Chem 273, 10682-9. |
Western blot analysis of recombinant proteins containing the kinase domain of Jak1, Jak2 and Jak3 (5 ng each), using Jak3 Antibody.Western免疫印迹。用Jak3 Antibody研究融合蛋白包含Jak1, Jak2 和 Jak3 (每个5 ng) 。 | |
Western blot analysis of extracts from Jurkat cells, using Jak3 Antibody.Western免疫印迹。用Jak3 Antibody研究 Jurkat 细胞的细胞提取液。 |
