| 货号 | 2881T |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ERp57 (G117) Antibody detects endogenous levels of total ERp57 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Secretory proteins translocate into the endoplasmic reticulum (ER) after their synthesis where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds (1). This process is called oxidative protein folding. Disulfide isomerase (PDI) has two thioredoxin homology domains and catalyzes the formation and isomerization of these disulfide bonds (2). Other ER resident proteins that possess the thioredoxin homology domains, including endoplasmic reticulum stress protein 57 (ERp57), constitute the PDI family (2). ERp57 interacts with calnexin and calreticulin (3) and is suggested to play a role in the isomerization of disulfide bonds on certain glycoproteins (3). |
| 存放说明 | -20C |
| 计算分子量 | 57 |
| 参考文献 | 1 . Huppa, J.B. and Ploegh, H.L. (1998) Cell 92, 145-8. 2 . Ellgaard, L. and Ruddock, L.W. (2005) EMBO Rep. 6, 28-32. 3 . Jessop, C.E. et al. (2007) EMBO J 26, 28-40. |
Western blot analysis of extracts from various cell types using ERp57 (G117) Antibody. 对多个细胞系使用ERp57 (G117) Antibody进行Western blot分析。 |
