| 货号 | 4952T |
| 反应种属 | Human,Mouse,Rat, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | c-IAP1 Antibody detects endogenous levels of c-IAP1. At physiological levels, cross reactivity was not detected with other family members. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2). |
| 存放说明 | -20C |
| 计算分子量 | 62 |
| 参考文献 | 1 . Deveraux, Q.L. and Reed, J.C. (1999) Genes Dev 13, 239-52. 2 . Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223. 3 . Altieri, D.C. et al. (1999) Lab Invest 79, 1327-33. 4 . Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803. 5 . Kasof, G.M. and Gomes, B.C. (2001) J Biol Chem 276, 3238-46. 6 . Deveraux, Q.L. et al. (1997) Nature 388, 300-4. |
Western blot analysis of extracts from Jurkat, HeLa, and HT29 cells, using c-IAP1 Antibody. Western blot 免疫印迹。用c-IAP1 Antibody研究Jurkat、HeLa 和HT29 细胞的细胞提取液。 |
