| 货号 | 3810T |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Rabbit |
| 应用 | WB, IP |
| 目标/特异性 | Enolase-1 Antibody detects endogenous levels of total enolase-1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Enolase is an important glycolytic enzyme involved in the interconversion of 2-phosphoglycerate to phosphoenolpyruvate. Mammalian enolase exists as three subunits: enolase-1 (α-enolase), enolase-2 (γ-enolase) and enolase-3 (β-enolase) that can form both homo- and heterodimers. Expression of the enolase isoforms differs in a tissue specific manner (1). Enolase-1 plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion (2,3). Abnormal expression of enolase-1 is associated with tumor progression in some cases of breast and lung cancer (4-7). Alternatively, an enolase-1 splice variant (MBP-1) binds the c-myc promoter p2 and may function as a tumor suppressor. For this reason enolase-1 is considered as a potential therapeutic target in the treatment of some forms of cancer (8). |
| 存放说明 | -20C |
| 计算分子量 | 47 |
| 参考文献 | 1 . Pancholi, V. (2001) Cell Mol Life Sci 58, 902-20. 2 . Redlitz, A. et al. (1995) Eur J Biochem 227, 407-15. 3 . Jiang, B.H. et al. (1997) Cancer Res 57, 5328-35. 4 . Peebles, K.A. et al. (2003) Carcinogenesis 24, 651-7. 5 . Zhang, L. et al. (2000) J Surg Res 93, 108-19. 6 . Wu, W. et al. (2002) Clin Exp Metastasis 19, 319-26. 7 . Hennipman, A. et al. (1988) Tumour Biol 9, 241-8. 8 . Feo, S. et al. (2000) FEBS Lett 473, 47-52. |
Western blot analysis of extracts from various cell types using Enolase-1 Antibody. Wetern blot检测多种细胞提取物，所用抗体为Enolase-1 Antibody。 |
