SOCS1 (A156) Antibody
货号：
3950T 基本售价：
1350.0 元 规格：
-
产品信息
概述| 货号 | 3950T |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | SOCS1 (A156) Antibody detects endogenous levels of total SOCS1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The SOCS (suppressor of cytokine signaling) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway (1-3). The SOCS family consists of at least 8 members including the originally identified protein CIS1 (cytokine-inducible SH2-containing protein) as well as SOCS1 through SOCS7. Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box. These proteins are important regulators of cytokine signaling, proliferation, differentiation and immune responses. |
| 存放说明 | -20C |
| 计算分子量 | 23 |
| 参考文献 | 1 . Alexander, W.S. et al. (1999) J Leukoc Biol 66, 588-92.
2 . Chen, X.P. et al. (2000) Immunity 13, 287-90.
3 . Hilton, D.J. et al. (1998) Proc Natl Acad Sci USA 95, 114-9.
4 . Endo, T.A. et al. (1997) Nature 387, 921-4.
5 . Naka, T. et al. (1997) Nature 387, 924-9.
6 . Ohya, K. et al. (1997) J Biol Chem 272, 27178-82.
7 . Kinjyo, I. et al. (2002) Immunity 17, 583-91.
8 . Davey, G.M. et al. (2006) Tissue Antigens 67, 1-9.
9 . Starr, R. et al. (1997) Nature 387, 917-21.
10 . Marine, J.C. et al. (1999) Cell 98, 609-16.
11 . De Sepulveda, P. et al. (1999) EMBO J 18, 904-15.
12 . Kamizono, S. et al. (2001) J Biol Chem 276, 12530-8.
13 . Rottapel, R. et al. (2002) Oncogene 21, 4351-62.
14 . Rui, L. et al. (2002) J Biol Chem 277, 42394-8.
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参考图片Western blot analysis of extracts from COS-7 cells, untransfected (-) or transfected with a construct overexpressing human SOCS1 (+), using SOCS1 (A156) Antibody.Western免疫印迹。用SOCS1 (A156) Antibody研究未经转染 (-) 或转染了过表达人源SOCS1 (+)的COS-7细胞的细胞提取液。 |
Western blot analysis of extracts from BaF3 cells starved of mouse IL-3 and serum overnight, untreated (-) or mouse IL-3-treated (10 ng/ml, 6 hr; +) and NK-92 cells starved of human IL-2 and serum overnight, untreated (-) or human IL-2-treated (10 ng/ml, 6 hr; +), using SOCS1 (A156) Antibody. |
