| 货号 | 4038T |
| 反应种属 | Human,Mouse,Monkey, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | KLF4 Antibody detects endogenous levels of total KLF4 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | KLF4 is a member of the erythroid Kruppel-like factor (EKLF) multigene family that is highly expressed in the differentiating layers of the epidermis (1, 2). KLF4 plays a critical role in the differentiation of epithelial cells and is essential for normal gastric homeostasis (2,3). Depending on the target gene, KLF4 can function as both a repressor and activator of transcription (4). Research studies suggest this protein may function as either a tumor suppressor or an oncogene depending on tumor type, with up-regulation in human squamous cell carcinoma of the head and neck and down-regulation in colorectal carcinoma (5,6). The in vitro reprogramming of somatic cells to an embryonic-like state has been achieved by retroviral transduction of four factors: Oct-3/4, Sox2, c-Myc, and KLF4 (7). These induced pluripotent stem cells (iPS) are of great therapeutic interest as they exhibit the key characteristics and growth properties of pluripotent stem cells (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 65 |
| 参考文献 | 1 . Yet, S.F. et al. (1998) J Biol Chem 273, 1026-31. 2 . Segre, J.A. et al. (1999) Nat Genet 22, 356-60. 3 . Katz, J.P. et al. (2005) Gastroenterology 128, 935-45. 4 . Evans, P.M. and Liu, C. (2008) Acta Biochim Biophys Sin (Shanghai) 40, 554-64. 5 . Foster, K.W. et al. (2005) Oncogene 24, 1491-500. 6 . Rowland, B.D. and Peeper, D.S. (2006) Nat Rev Cancer 6, 11-23. 7 . Takahashi, K. and Yamanaka, S. (2006) Cell 126, 663-76. 8 . Meissner, A. et al. (2007) Nat Biotechnol 25, 1177-81. 9 . Park, I.H. et al. (2008) Nature 451, 141-6. |
Western blot analysis of extracts from various cell lines using KLF4 antibody.使用KLF4抗体对多种细胞提取物进行western blot分析。 |
