| 货号 | 4470T |
| 反应种属 | Human, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | RagD Antibody detects endogenous levels of total RagD protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | mTORC1 kinase complex is a critical component in regulating cell growth (1,2). Its activity is modulated by energy levels, growth factors and amino acids (3,4). Recent studies found that RagA, RagB, RagC and RagD, the four related GTPases, interact with raptor in mTORC1 (1,2). These interactions are both necessary and sufficient for mTORC1 activation in response to amino acid signals (1,2).RagD is one of several genes differentially expressed in human melanoma cell lines and has been considered as a viable target for further diagnostic and therapeutic study (5). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . Sancak, Y. et al. (2008) Science 320, 1496-501. 2 . Kim, E. et al. (2008) Nat Cell Biol 10, 935-45. 3 . Hay, N. and Sonenberg, N. (2004) Genes Dev 18, 1926-45. 4 . Wullschleger, S. et al. (2006) Cell 124, 471-84. 5 . de Wit, N.J. et al. (2005) Br J Cancer 92, 2249-61. |
Western blot analysis of extract from 293 cells using RagD Antibody. Western blot 分析293 细胞的提取物，所用抗体为RagD Antibody。 | |
Western blot analysis of extracts from various cell lines using RagD Antibody. |
