| 货号 | 4705T |
| 反应种属 | Human,Mouse,Monkey, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | Integrin α5 Antibody detects endogenous levels of total integrin α5 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis (4,5). By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization (6). |
| 存放说明 | -20C |
| 计算分子量 | 150 |
| 参考文献 | 1 . Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71. 2 . Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100. 3 . van der Flier, A. and Sonnenberg, A. (2001) Cell Tissue Res 305, 285-98. 4 . Kabir-Salmani, M. et al. (2004) Mol Hum Reprod 10, 91-7. 5 . Kim, S. et al. (2000) J Biol Chem 275, 33920-8. 6 . Miyamoto, S. et al. (1995) J Cell Biol 131, 791-805. |
Western blot analysis of extracts from A549, NIH/3T3 and COS cell lines using Integrin α5 Antibody.使用整合素α5抗体对 A549, NIH/3T3 和COS 细胞提取物进行western blot分析。 |
