| 货号 | 4711T |
| 反应种属 | Human,Rat, |
| 来源宿主 | Rabbit |
| 应用 | WB, IP |
| 目标/特异性 | Integrin αV Antibodies detects endogenous levels of total integrin αV protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2). Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer (10-12). |
| 存放说明 | -20C |
| 计算分子量 | 135, 140 |
| 参考文献 | 1 . Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71. 2 . Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100. 3 . Koistinen, P. et al. (2004) Int J Cancer 112, 61-70. 4 . Davidson, B. et al. (2003) Gynecol Oncol 90, 248-57. 5 . Schwartz, E.A. et al. (1999) Circ Res 84, 315-22. 6 . Suzuma, K. et al. (1998) Invest Ophthalmol Vis Sci 39, 1028-35. 7 . Eliceiri, B.P. and Cheresh, D.A. (1999) J Clin Invest 103, 1227-30. 8 . Friedlander, M. et al. (1995) Science 270, 1500-2. 9 . Perruzzi, C.A. et al. (2003) J Invest Dermatol 120, 1100-9. 10 . Strieth, S. et al. (2006) Int J Cancer 119, 423-31. 11 . Kumar, C.C. (2003) Curr Drug Targets 4, 123-31. 12 . Tucker, G.C. (2006) Curr Oncol Rep 8, 96-103. |
Western blot analysis of extracts from A549 and C6 cells using Integrin αV Antibody.使用整合素αV 抗体对A549 和C6细胞提取物进行western blot分析。 |
