| 货号 | 2032T |
| 反应种属 | Human,Mouse,Rat, |
| 来源宿主 | Rabbit |
| 应用 | WB, IHC-P |
| 目标/特异性 | Lamin A/C Antibody detects endogenous levels of total full length lamin A (and lamin C) (70 kDa), as well as the small fragment of lamin A (and lamin C) resulting from cleavage at aspartic acid 230 (28 kDa). |
| 使用方法 | WB(1:1000) IHC-P (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 28, 70 |
| 参考文献 | 1 . Gruenbaum, Y. et al. (2000) J Struct Biol 129, 313-23. 2 . Yabuki, M. et al. (1999) Physiol Chem Phys Med NMR 31, 77-84. 3 . Goldberg, M. et al. (1999) Crit Rev Eukaryot Gene Expr 9, 285-93. 4 . Orth, K. et al. (1996) J Biol Chem 271, 16443-6. 5 . Oberhammer, F.A. et al. (1994) J Cell Biol 126, 827-37. 6 . Rao, L. et al. (1996) J Cell Biol 135, 1441-55. |
Immunohistochemical staining of paraffin-embedded human breast tumor, showing staining of the nuclear envelope, using Lamin A/C Antibody. | |
免疫组织化学分析石蜡包埋的人乳腺癌切片，显示了核包膜的染色情况，使用抗体为 Lamin A/C Antibody 。 | |
