| 货号 | 4758T |
| 反应种属 | Human,Rat, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | DcR3 Antibody detects endogenous levels of total DcR3. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1,2). The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases. Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand (3-5). Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity (6-8). |
| 存放说明 | -20C |
| 计算分子量 | 32 |
| 参考文献 | 1 . Nagata, S. (1997) Cell 88, 355-65. 2 . Thorburn, A. (2004) Cell Signal 16, 139-44. 3 . Sheridan, J.P. et al. (1997) Science 277, 818-21. 4 . Marsters, S.A. et al. (1997) Curr Biol 7, 1003-6. 5 . Pitti, R.M. et al. (1998) Nature 396, 699-703. 6 . Liu, X. et al. (2005) Cancer Res 65, 9169-75. 7 . Spalding, A.C. et al. (2002) Oncogene 21, 260-71. 8 . Bernard, D. et al. (2001) J Biol Chem 276, 27322-8. |
Western blot analysis of lysates from LN18, HeLa and HCT116 cell lines, using DcR3 Antibody. Western blot 检测 LN18、HeLa和HCT116 细胞系裂解液，使用抗体为DcR3 Antibody。 |
