| 货号 | 4592T |
| 反应种属 | Human, |
| 来源宿主 | Rabbit |
| 应用 | WB, IHC-P |
| 目标/特异性 | Bik Antibody detects endogenous levels of Bik protein. It does not cross-react with other Bcl-2 family members. |
| 使用方法 | WB(1:1000) IHC-P (1:75) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Bik/Nbk (Bcl-2-interacting killer/natural born killer) is a potent pro-apoptotic protein belonging to a group of Bcl-2 family members that includes Bad, Bid, Bim, Hrk, and Noxa, containing a BH3 domain but lacking other conserved domains, BH1 or BH2 (1,2). Functionally, Bik is able to bind to and antagonize anti-apoptotic Bcl-2 family members including Bcl-2, Bcl-xL, and viral homologs E1B-19K and EBV-BHFR1. The BH3 domain of Bik is essential for its apoptotic activity and interaction with survival proteins (3). Phosphorylation of Bik is correlated with an increase in its pro-apoptotic activity (4). |
| 存放说明 | -20C |
| 计算分子量 | 20 |
| 参考文献 | 1 . Boyd, J.M. et al. (1995) Oncogene 11, 1921-8. 2 . Han, J. et al. (1996) Mol Cell Biol 16, 5857-64. 3 . Tong, Y. et al. (2001) Mol Cancer Ther 1, 95-102. 4 . Verma, S. et al. (2001) J Biol Chem 276, 4671-6. |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, showing cytoplasmic localization, using Bik Antibody. 免疫组织化学分析石蜡包埋的人肺癌切片，显示细胞质定位，使用抗体为Bik Antibody。 | |
Western blot analysis of extracts from Raji and Ramos cell lines using Bik Antibody. Western blot 检测Raji和Ramos 细胞系提取物，使用抗体为Bik Antibody。 | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using Bik Antibody. 免疫组织化学分析石蜡包埋的人结肠癌切片，使用抗体为Bik Antibody。 |
