XPC Antibody
货号：
12701T 基本售价：
1350.0 元 规格：
-
产品信息
概述| 货号 | 12701T |
| 反应种属 | Human, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | XPC Antibody recognizes endogenous levels of total XPC protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Nucleotide excision repair (NER) is a process by which cells identify and repair DNA lesions resulting from chemical or radiation exposure (1). XPC forms a complex with HR23B (2) that acts as a damage sensor due to its high affinity for geometry distorting DNA lesions. This complex localizes to sites of DNA damage and recruits the remaining members of the preincision complex necessary for initiation of NER (3). XPC is one of eight NER proteins (XPA-G, XPV) where defects result in Xeroderma pigmentosum, a disease characterized by sunlight sensitivity, a predisposition to cancer of exposed tissue, and, in some instances, neurological defects (4).核苷酸切除修复（NER）是细胞承受了化学物质或辐射暴露后识别并修复DNA损伤的过程（1）。XPC与HR23B形成复合物（2），并且由于其对扭转的DNA损伤结构的高亲和性，可以作为损伤的感受器。这个复合物定位在DNA损伤的部位募集那些起始NER的复合物（3）。XPC是八个NER蛋白（XPA-G, XPV）的其中之一，XPC发生缺陷会导致着色性干皮病，一种对日光敏感的疾病，暴露的组织易患癌症，某些情况下可能会导致神经功能受损（4）。 Application References |
| 存放说明 | -20C |
| 计算分子量 | 120 |
参考图片Western blot analysis of extracts from various cell lines using XPC Antibody.使用XPC抗体对多种细胞提取物进行western blot分析。 |
