| 货号 | MAB2005-SP |
| 别名 | AHUS2; CD46 antigen; CD46 molecule, complement regulatory protein; CD46; MCP; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLXcomplement regulatory protein; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen |
| 反应种属 | Human |
| 应用 | Western Blot(1 µg/mL) Flow Cytometry(2.5 µg/106cells) |
| 目标/特异性 | Detects human CD46 in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 1 µg/mL Flow Cytometry: 2.5 µg/106cells |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4179 (Human); 17221 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b. | |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human CD46 Cys35-Asp328 Accession # NP_722548 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | CD46, also known as MCP, is a type I membrane protein that functions asa cofactor for Complement Factor I-mediated inactivation of complementcomponents C3b and C4b. CD46 is expressed in white blood cells,platelets, epithelial cells, and fibroblasts. The extracellular regionof CD46 contains four tandem Sushi domains. At least fourteentranscript variants encode isoforms with deletions or substitutionsfollowing the fourth Sushi domain. Within corresponding regions, humanCD46 shares 50% amino acid sequence identity with mouse and rat CD46. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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