Human PAR2 MAb (Clone 344222) (25 UG)【科瑞奥博】

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Human PAR2 MAb (Clone 344222) (25 UG)

货号： MAB3949-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB3949-SP
别名	CFIIRL1; coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; F2RL1; GPCR11; GPR11protease-activated receptor 2; G-protein coupled receptor 11; PAR-2; PAR2G protein-coupled receptor-11; proteinase-activated receptor 2; proteinase-activated receptor-2; Thrombin receptor-like 1
全称	Protease-Activated Receptor 2
反应种属	Human
应用	Flow Cytometry(2.5 µg/10⁶cells)
目标/特异性	Detects human PAR2. Stains human PAR2 transfectants but not irrelevant transfectants.
使用方法	Flow Cytometry: 2.5 µg/10⁶cells
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2150 (Human); 14063 (Mouse); 116677 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Structural insight into allosteric modulation of protease-activated receptor 2 Authors: RKY Cheng, C Fiez-Vanda, O Schlenker, K Edman, B Aggeler, DG Brown, GA Brown, RM Cooke, CE Dumelin, AS Doré, S Geschwindn, C Grebner, NO Hermansson, A Jazayeri, P Johansson, L Leong, R Prihandoko, M Rappas, H Soutter, A Snijder, L Sundström, B Tehan, P Thornton, D Troast, G Wiggin, A Zhukov, FH Marshall, N Dekker Nature, 2017;545(7652):112-115. Species: Human Sample Type: Whole Cells Application: Binding Model
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	NS0 mouse myeloma cell line transfected with human PAR2 Accession # P55085
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Protease-Activated Receptor 2 (PAR2) is a protease activated 7-transmembrane G-protein-coupled receptor. Human PAR2 contains a cleavage site for trypsin, mast cell tryptase or coagulation factor VIIa or Xa, 11 amino acids (aa) C-terminal to the signal sequence. Cleavage creates a tethered ligand that activates the 361 aa receptor. PAR2 is expressed in kidney, pancreas, stomach, intestine, airway, skin, bladder and brain; activation stimulates release of inflammatory and nociceptive mediators. PAR2 is downregulated by ubiquination, endocytosis and degradation. Mature human PAR2 shows 78% amino acid identity with mouse PAR2 over the extracellular portions.
运输条件	Blue Ice
存放说明	4℃
参考文献	Coagulation Neurotransmitter Receptors Neurotransmitter Receptors, Transporters, and Ion Channels

参考图片

Detection of PAR2 in HT‑29 Human Cell Line by Flow Cytometry. HT‑29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human PAR2 Monoclonal Antibody (Catalog # MAB3949, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab)₂ Secondary Antibody (Catalog # F0102B).