| 货号 | MAB30601-SP |
| 别名 | Gut homing receptor beta subunit; integrin beta 7 subunit; integrin beta-7; integrin, beta 7; ITGB7 |
| 反应种属 | Mouse |
| 应用 | Adhesion Activation |
| 目标/特异性 | Detects mouse Integrin beta 7 extracellular domain in direct ELISAs. |
| 使用方法 | Adhesion Activation: The adhesion of TK-1 mouse T cell lymphoma cells (5 x 104 cells/well, treated with 1 mM MnCl2) to immobilized Recombinant Mouse MAdCAM-1 Fc Chimera (Catalog # 993-MC, 1 µg/well, 100 µL/well) was maximally enhanced (2‑2.5 fold) by 10 µg/mL of the antibody. |
| 来源 | Monoclonal Rat IgG2A Clone # 332408 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3695 (Human); 16421 (Mouse); 25713 (Rat) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin beta 7 Glu20-His722 Accession # P26011 |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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