| 货号 | MAB3850-SP |
| 别名 | C14orf141; GLC3D; latent transforming growth factor beta binding protein 2; latent-transforming growth factor beta-binding protein 2; LTBP2; LTBP-2; LTBP3chromosome 14 open reading frame 141; MSTP031 |
| 反应种属 | Human |
| 应用 | Western Blot(1 µg/mL) |
| 目标/特异性 | Detects human Latent TGF‑ beta bp2/LTBP‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LTMP-4 is observed. |
| 使用方法 | Western Blot: 1 µg/mL |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4053 (Human) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Latent TGF‑ beta bp2/LTBP‑2 Gln36-Glu1821 Accession # NP_000419 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | LTBP-2 is a 240 kDa member of the LTBP and fibrillin families. Unlike other LTBP, LTBP-2 is not a component of the large latent TGF-beta complex. LTBP-2 is a secreted calcium-binding extracellular matrix glycoprotein of elastic tissue 10 nm microfibrils, especially in the lung. The 1786 aa mature human LTBP2 contains 20 EGF‑like domains and four 8-cysteine repeats and shares 80% aa identity with mouse LTBP-2. An RGD sequence and a proline-rich sequence may mediate adhesion of melanoma cells, but for fibroblasts LTBP-2 may actually be an antiadhesion protein. In vivo, proteolysis by plasmin and elastase is likely and may cleave putative adhesion sites. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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