| 货号 | MAB723-SP |
| 别名 | TAJ; TAJ-alpha; TAJToxicity and JNK inducer; TNFRSF19; TRADE; TROYtumor necrosis factor receptor superfamily member 19; tumor necrosis factor receptor superfamily, member 19 | 全称 | Tumor Necrosis Factor Receptor Superfamily, Member 19 |
| 反应种属 | Mouse |
| 应用 | Western Blot(1 µg/mL) |
| 目标/特异性 | Detects mouse TROY/TNFRSF19 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant mouse (rm) 4‑1BB, rmBAFF R, recombinant human RELT, rmCD3, rhDR6, rmDR3, rhTRADD, rmEDAR, recombinant rat FAS, rmFAS, rmGITR, rmHVEM, rmLymphotoxin beta R, rmNGF R, rmOPG, rmRANK, rmTNF RII, rmDcTRAIL R2, rmDcTRAIL RI, rmOX40, rhTRAIL R3, rhTNF RII, rmTWEAK, rmTRAIL, rmCD27, rmCD40, rhTNF RI, or rmTNF RI is observed. |
| 使用方法 | Western Blot: 1 µg/mL |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 55504 (Human); 29820 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TROY/TNFRSF19 Glu30-Leu170 Accession # Q9JLL3 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | TROY (also known as TAJ and TNFRSF19) is a 45‑55 kDa member of the TNF receptor superfamily of molecules (1‑4). It is widely expressed in the embryo, but shows limited expression in adult. In particular, embryonic TROY is found in embryonic epithelium, neural tube, and mesenchyme, and developing neurons of the hippocampus and thalamus (5, 6). In the adult, TROY is found in the nervous system associated with dorsal root and retinal ganglia neurons, astrocytes, and microglia, and in hair follicles where it is expressed by dermal papilla matrix cells (4, 7, 8, 9). In human, TROY has also been found on melanoma cells, not normal melanocytes (10). TROY is reportedly a component of the Nogo-A receptor, taking the place of p75 in a membrane-bound LINGO-1:NgR1:TROY complex (6 8, 9). This complex purportedly mediates axon repulsion initiated by one of five myelin-associated inhibitory factors (OMpg; CD100; Ephrin B3; Nogo-A; MAG) (6, 11). In the hair follicle, TROY binds LTa and acts with Eda to drive secondary hair follicle development (4, 12). Mature human TROY is a 394 amino acid (aa) type I transmembrane protein (1‑3). It possesses a 141 aa extracellular region (aa 30‑170) that contains three 40 aa TNFR cysteine motifs, and an extended 232 aa cytoplasmic domain (aa 192‑423). There is one potential isoform that shows a two aa substitution for aa 416 ‑ 423. The extracellular domains of human and mouse TROY share 90% aa identity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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