Canine IL-18/IL-1F4 MAb (Clone 314811) (25 UG)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Canine IL-18/IL-1F4 MAb (Clone 314811) (25 UG)

货号： MAB29241-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB29241-SP
别名	Iboctadekin; IFN-gamma-inducing factor; IGIF; IGIFIL-1 gamma; IL-18MGC12320; IL-1F4; IL1F4iboctadekin; IL-1g; Interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; interleukin-18
全称	Interleukin 18
反应种属	Canine
应用	Western Blot(1 µg/mL) Immunocytochemistry(8-25 µg/mL)
目标/特异性	Detects canine IL‑18/IL‑1F4 in direct ELISAs and Western blots.
使用方法	Western Blot: 1 µg/mL Immunocytochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3606 (Human); 16173 (Mouse); 29197 (Rat); 397057 (Porcine); 574151 (Primate)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant canine IL‑18/IL‑1F4 Tyr37-Ser193 Accession # Q9XSR0
生物活性	Canine
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Interleukin 18, also known as interferon-gamma-inducing factor (IGIF) or IL-1 gamma, is an 18 kDa member of the IL-1 superfamily which shares biologic activities with IL‑12. IL-18 is expressed by liver cells, monocyte/macrophages, osteoblasts and keratinocytes. Mature canine IL-18 shares 73% sequence identity with human IL-18. Caspase-1 (IL-1 beta-converting enzyme) has been shown to process pro-IL-18 to active IL-18. Human IL-18 has been shown to enhance NK cell activity, induce the production of IFN-gamma and GM-CSF and inhibit the production of IL-10 by PBMCs.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cytokines and Receptors in Angiogenesis Group 1 ILCs IL-1 Family Inflammasomes: Intracellular Regulators of Pathogen Interactive Pathway: IL-1 Family Signaling Pathways Isolation, Culture, and Identification of Natural Killer Cells Macrophage Activation Markers Mini-review: Interleukin 18 (IL-18) Multiple Sclerosis and Myelin Related Molecules Neuroinflammation NOD-like Receptors and the Inflammasome T Cell Cytokine Signaling Th1 Cells The Nlrp3 Inflammasome & IL-18 Regulate Intestinal Homeostasis

参考图片

IL-18/IL-1F4 in Canine PBMCs.
IL-18/IL-1F4 was detected in immersion fixed canine peripheral blood mononuclear cells (PBMCs) using Mouse Anti-Canine
IL-18/IL-1F4 Monoclonal Antibody (Catalog # MAB29241) at 25 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.