Human MDL-1/CLEC5A MAb (Clone 283834) (25 UG)【科瑞奥博】

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Human MDL-1/CLEC5A MAb (Clone 283834) (25 UG)

货号： MAB2384-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB2384-SP
别名	CLEC5A; CLECSF5; CLECSF5carbohydrate-recognition domain) lectin, superfamilymember 5; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL-1MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1
全称	Myeloid DAP12-associating Lectin
反应种属	Human
应用	Western Blot(1 µg/mL) Flow Cytometry(0.25 µg/10⁶cells)
目标/特异性	Detects human MDL‑1/CLEC5A in Western blots. Does not cross-react with recombinant mouse MDL‑1.
使用方法	Western Blot: 1 µg/mL Flow Cytometry: 0.25 µg/10⁶cells
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	23601 (Human); 23845 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Atypical Activin A and IL-10 Production Impairs Human CD16+ Monocyte Differentiation into Anti-Inflammatory Macrophages. Authors: Gonzalez-Dominguez E, Dominguez-Soto A, Nieto C, Flores-Sevilla J, Pacheco-Blanco M, Campos-Pena V, Meraz-Rios M, Vega M, Corbi A, Sanchez-Torres C J Immunol, 2016;196(3):1327-37. Species: Human Sample Type: Whole Cells Application: Flow Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies. Authors: Wortham B, Eppert B, Flury J, Garcia S, Donica W, Osterburg A, Joyce-Shaikh B, Cua D, Borchers M J Immunol, 2015;0(0):. Species: Human Sample Type: Whole Cells Application: Flow Comparison of gene expression profiles between human and mouse monocyte subsets. Authors: Ingersoll MA, Spanbroek R, Lottaz C Blood, 2010;115(3):e10-9. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human MDL‑1/CLEC5A Tyr26-Lys188 Accession # Q9NY25
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	MDL-1 is anapproximately 40 kDa transmembrane glycoprotein belonging to the C-type lectinsuperfamily (CLEC5A). MDL-1 is expressed on immature myeloid cells, monocytes,macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. Itcontains a charged lysine in the transmembrane region that enables it toassociate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses duringautoimmune arthritis and upon binding to Dengue and Japanese encephalitis viruses.The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalk regionand one C-type lectin domain. Within the ECD, human and mouse MDL-1 share 67%amino acid sequence identity.
运输条件	Blue Ice
存放说明	4℃
参考文献	C-type Lectin Family C-type Lectin Receptors Dendritic Cell Activation Dendritic Cell ITIM/ITAM Immunoreceptors ITIM/ITAM Immunoreceptors and Related Molecules

参考图片

Detection of MDL‑1/CLEC5A in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with (A) MouseAnti-Human Siglec-3/CD33 APC-conjugated Monoclonal Antibody (Catalog # FAB1137A) and (B) Mouse Anti-Human MDL‑1/CLEC5A Monoclonal Antibody (Catalog # MAB2384, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).