Human p38 beta MAb (Clone 280071) (25 UG)【科瑞奥博】

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Human p38 beta MAb (Clone 280071) (25 UG)

货号： MAB3274-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB3274-SP
别名	EC 2.7.11; EC 2.7.11.24; MAP kinase 11; MAP kinase p38 beta; MAPK 11; MAPK11; mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; p38b; p38Beta; P38BETA2; PRKM11; SAPK2B; SAPK2p38-2P38B; Stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase-2b
反应种属	Human
应用	Immunocytochemistry(8-25 µg/mL)
目标/特异性	Detects human p38 beta in direct ELISAs. No cross-reactivity with recombinant human p38 alpha, gamma, or delta is observed.
使用方法	Immunocytochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	5600 (Human); 19094 (Mouse)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Human p38 beta synthetic peptide EPPKPPGSLEIEQ Accession # NP_002742
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	The p38 mitogen-activated protein kinases (p38 MAP kinases) are a family of four related Ser/Thr kinases responsive to pro-inflammatory cytokines and environmental stresses, including ionizing radiation, oxidative stress, and osmotic shock. Each family member, p38 alpha, p38 beta, p38δ, and p38 gamma, is activated by dual Thr and Tyr phosphorylation within a Thr-Gly-Tyr motif residing in the kinase activation loop. For p38 beta, also known as p38-2, stress-activated protein kinase 2B (SAPK2B), and MAPK11, this dual phosphorylation occurs at Thr180/Tyr182.
运输条件	Blue Ice
存放说明	4℃
参考文献	Airway Inflammation and Remodeling Apoptosis Intracellular Kinases Chemokine Receptor Intracellular Signaling C-type Lectin Receptors Diabetic Peripheral Neuropathy GDNF Family IL-1 Family IL-17 Family Intracellular Kinases Intracellular Kinases in the Akt Pathway Neurotrophin/Trk Family NOD-like Receptors and the Inflammasome Positive Regulators of the Jak/STAT Pathway Technical Notes: phospho-specific ELISAs TNF Superfamily Regulators Toll-Like Receptors VEGF Family

参考图片

p38 beta in Jurkat Human Cell Line. p38 beta was detected in immersion fixed Jurkat human acute T cell leukemia cell line using Mouse Anti-Human p38 beta Monoclonal Antibody (Catalog # MAB3274) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.