Human Integrin alpha V/CD51 MAb (Clone 273210) (25 UG)【科瑞奥博】

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Human Integrin alpha V/CD51 MAb (Clone 273210) (25 UG)

货号： MAB12191-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB12191-SP
别名	antigen identified by monoclonal L230; CD51 antigen; CD51; integrin alpha-V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITGAV; MSK8; Vitronectin Receptor alpha; Vitronectin receptor subunit alpha; VNRA; VNRADKFZp686A08142
反应种属	Human
应用	Flow Cytometry(2.5 µg/10⁶cells) Immunocytochemistry(8-25 µg/mL)
目标/特异性	Detects human Integrin alpha V/CD51 in direct ELISAs.
使用方法	Flow Cytometry: 2.5 µg/10⁶cells Immunocytochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3685 (Human); 16410 (Mouse); 296456 (Rat)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Chinese hamster ovary cell line CHO-derived recombinant human Integrin alpha V/CD51 Phe31-Val992 Accession # NP_002201
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Integrin alpha V (CD51; also vitronectin receptor subunit alpha) is a 140‑150 kDa member of the integrin alpha -chain family of adhesion molecules. It forms disulfide-linked integral membrane heterodimers with at least five beta -chains, including beta 1, 3, 5, 6 and 8. Human alpha V is a 1018 aa type I transmembrane glycoprotein that contains a 962 aa extracellular domain (ECD) and a short 32 aa cytoplasmic tail. The ECD contains seven FG (PheAlaGly)-GAP (GlyAlaPro) repeats that form a beta -propellor domain (aa 46‑483). Furin cleavage of the alpha V ECD occurs after Gly889, generating a disulfide-linked heteromeric subunit alpha V chain. alpha V-containing integrins bind multiple ECM molecules, including vitronectin, osteopontin, MMP-2 and TSP. The ECD of human alpha V shares 92% and 90% aa sequence identity with mouse and rat alpha V ECD, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	Actin Stress Fibers and Focal Adhesions During EMT Adhesion Molecules Endothelial Cell Markers and Adhesion Molecules in Angiogenesis Epithelial Cell Polarity HGF/SF Activation of Integrins Human CD Marker Products ICC / IHC Images: Integrin alpha V/CD51 Integrin Ligands at a Glance (J. Cell. Sci.) Integrin Subunit Interactions Integrins and Associated Molecules Mesenchymal Stem Cell Markers Osteoblast and Osteoclast Markers VEGF Family

参考图片

Integrin alpha V/CD51 in Rat Mesenchymal Stem Cells. Integrin alpha V/CD51 was detected in immersion fixed rat mesenchymal stem cells using Mouse Anti-Human Integrin alpha V/
CD51 Monoclonal Antibody (Catalog # MAB12191) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.