Mouse Dkk-1 MAb (Clone 259631) (25 UG)【科瑞奥博】

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Mouse Dkk-1 MAb (Clone 259631) (25 UG)

货号： MAB1765-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB1765-SP
别名	dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-related protein 1; DKK-1; hDkk-1; SKdickkopf-1 like
全称	Dickkopf-1
反应种属	Mouse
应用	Western Blot(1 µg/mL) Immunohistochemistry(8-25 µg/mL)
目标/特异性	Detects mouse Dkk-1 in direct ELISAs and Western blots. Does not cross-react with recombinant human Dkk-1, -3, or -4.
使用方法	Western Blot: 1 µg/mL Immunohistochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	22943 (Human); 13380 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis. Authors: Gustafson B, Eliasson B, Smith U Diabetologia, 2010;53(3):536-40. Species: Mouse Sample Type: Cell Lysates Application: WB Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance. Authors: Gustafson B, Smith U J. Biol. Chem., 2010;285(18):14031-41. Species: Mouse Sample Type: Cell Lysates Application: WB Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice. Authors: Oyama T, Yamada Y, Hata K, Tomita H, Hirata A, Sheng H, Hara A, Aoki H, Kunisada T, Yamashita S, Mori H Carcinogenesis, 2008;29(3):666-72. Species: Mouse Sample Type: Whole Tissue Application: IHC Paraffin-embedded
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse Dkk-1 Ser30-His272 Accession # O54908
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Dkk-1 is a Dickkopf-related protein that inhibits Wnt signaling by binding the Wnt co-receptor LRP5/6. It also binds Kremen-1 and Kremen-2. Dkk-1 is important in embryonic development.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cancer Biomarkers Dkk-1: Upsetting the Balance in Rheumatoid Arthritis ICC / IHC Images: Dkk-1 Mini-review: DNA Damage Response Mini-review: Wnt Receptors & Pathways Negative Regulators of EMT New Tools: for Developmental Research Technical Notes: Wnt Inhibitor Activity Wnt Family Wnt Inhibitors Wnt: A polarizing factor in early mouse development

参考图片

Dkk‑1 in Mouse Embryo. Dkk‑1 was detected in immersion fixed frozen sections of mouse embryo (15 d.p.c) using Mouse Dkk‑1 Monoclonal Antibody (Catalog # MAB1765) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of epithelial cells in lung. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.