Human CXCL16 MAb (Clone 256213) (25 UG)【科瑞奥博】

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Human CXCL16 MAb (Clone 256213) (25 UG)

货号： MAB976-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB976-SP
别名	chemokine (C-X-C motif) ligand 16; CXC chemokine ligand 16; CXCL16; CXCLG16; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SCYB16; Small-inducible cytokine B16; SRPSOXC-X-C motif chemokine 16; SR-PSOXTransmembrane chemokine CXCL16
反应种属	Human
应用	Western Blot(1 µg/mL) Flow Cytometry(2.5 µg/10⁶cells)
目标/特异性	Detects human CXCL16 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human CXCL1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12/SDF-1 alpha,12/SDF-1 beta, 13, recombinant mouse CXCL1, 2, 6, 9, 10, 12/SDF-1 alpha, 13, 16, recombinant rat CXCL1, 2, 3/CINC-2 alpha, 3/CINC-2 beta, recombinant canine CXCL8, or recombinant porcine CXCL8 is observed.
使用方法	Western Blot: 1 µg/mL Flow Cytometry: 2.5 µg/10⁶cells Neutralization: Measured by its ability to neutralize CXCL16-induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with mouse CXCR6. Matloubian, M. et al. (2000) Nature Immunol. 1:298. The Neutralization Dose (ND₅₀) is typically 2-8 µg/mL in the presence of 20 ng/mL Recombinant Human CXCL16 Chemokine Domain.
来源	Monoclonal Rat IgG_2A Clone # 256213
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	58191 (Human); 66102 (Mouse)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human CXCL16 Asn49-Pro137 Accession # NP_071342
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	CXCL16 is a transmembrane protein with an extracellular domain consisting of a chemokine domain suspended on a mucin-like stalk. It functions as a ligand for the HIV co‑receptor, CXCR6 (Bonzo).
运输条件	Blue Ice
存放说明	4℃
参考文献	Astrocytes Secrete Neuroprotective Factors & Protect Against Glutamate-induced Neural Cell Apoptosis Chemokines and Receptors Chemokines and Receptors in Angiogenesis ICC / IHC Images: CXCL16 Infectious Diseases Macrophage Activation Markers Natural Killer T (NKT) Cells Scavenger Receptors

参考图片

Chemotaxis Induced by CXCL16 and Neutralization by Human CXCL16 Antibody. Recombinant Human CXCL16 Chemokine Domain (Catalog # 976-CX) chemoattracts the BaF3 mouse pro‑B cell line transfected with mouse CXCR6 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human CXCL16 Chemokine Domain (20 ng/mL) is neutralized (green line) by increasing concentrations of Human CXCL16 Monoclonal Antibody (Catalog # MAB976). The ND₅₀ is typically 2-8 µg/mL.