| 货号 | MAB1878-SP |
| 别名 | HCPH; PTP1C; PTPN6 | 全称 | Src Homology Region 2 Domain Phosphatase 1 |
| 反应种属 | Human |
| 应用 | Immunocytochemistry(8-25 µg/mL) |
| 目标/特异性 | Detects human SHP-1. |
| 使用方法 | Immunocytochemistry: 8-25 µg/mL |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5777 (Human); 15170 (Mouse); 116689 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. | |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | E. coli-derived recombinant human SHP-1 Ala205-Lys595 Accession # P29350 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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