| 货号 | MAB16992-SP |
| 别名 | antigen CD11b (p170); CD11 antigen-like family member B; CD11b antigen; CD11b; CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide); Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; CR3AMGC117044; Integrin alpha M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; MO1A; neutrophil adherence receptor alpha-M subunit; Neutrophil adherence receptor; SLEB6 |
| 反应种属 | Human |
| 应用 | Western Blot(1 µg/mL) |
| 目标/特异性 | Detects human CD11b/Integrin alpha M in direct ELISAs and Western blots. In Western blots no cross-reactivity with recombinant mouse (rm) Integrins alpha 2, alpha 3, alpha 4, alpha E or rhIntegrins alpha 5, alpha V, beta 1, beta 2, beta 3, or beta 6. |
| 使用方法 | Western Blot: 1 µg/mL |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3684 (Human); 16409 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. 1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-kappaB-dependent expression of CD55 in human monocytic THP-1 cells. | |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human CD11b/Integrin alpha M Phe17-Asn1105 Accession # NP_001139280 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | The Integrin family proteins are heterodimeric transmembrane receptorscomposed of an alpha and a beta subunit. The Integrin alpha M subunit, also knownas MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit(CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also knownas MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 isexpressed on granulocytes, macrophages, dendritic cells and naturalkiller cells. Upon activation, alpha M/ beta 2 can bind several ligands(including ICAM-1 fibrinogen and the C3 complement fragment C3bi) tomediate phagocyte adhesion, migration and ingestion ofcomplement-opsonized particles. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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