Human RUNX2/CBFA1 MAb (Clone 232902) (25 UG)【科瑞奥博】

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Human RUNX2/CBFA1 MAb (Clone 232902) (25 UG)

货号： MAB2006-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB2006-SP
别名	Acute myeloid leukemia 3 protein; AML3CCD; CBFA1; CBFA1MGC120022; Core-binding factor subunit alpha-1; MGC120023; PEA2-alpha A; PEBP2A; PEBP2A1CCD1; PEBP2aA1; PEBP2-alpha A; runt domain, alpha subunit 1; runt-related transcription factor 2; SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit
全称	Runt-related Transcription Factor 2
反应种属	Human
应用	Immunocytochemistry(8-25 µg/mL)
目标/特异性	Detects human RUNX2/CBFA1.
使用方法	Immunocytochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	860 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. GATA4 is essential for bone mineralization via ERalpha and TGFbeta/BMP pathways. Authors: Guemes M, Garcia A, Rigueur D, Runke S, Wang W, Zhao G, Mayorga V, Atti E, Tetradis S, Peault B, Lyons K, Miranda-Carboni G, Krum S J Bone Miner Res, 2014;29(12):2676-87. Species: Mouse Sample Type: whole cells Application: IHC Paraffin-embedded Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Authors: Kusumbe A, Ramasamy S, Adams R Nature, 2014;507(7492):323-8. Species: Mouse Sample Type: Whole Tissue Application: IHC Frozen Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Authors: Ramasamy S, Kusumbe A, Wang L, Adams R Nature, 2014;507(7492):376-80. Species: Mouse Sample Type: Whole Tissue Application: IHC Frozen Identification of a clonally expanding haematopoietic compartment in bone marrow. Authors: Wang L, Benedito R, Bixel M, Zeuschner D, Stehling M, Savendahl L, Haigh J, Snippert H, Clevers H, Breier G, Kiefer F, Adams R EMBO J, 2013;32(2):219-30. Species: Mouse Sample Type: Whole Tissue Application: IHC Fluorescence Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Authors: Pai A, Leaf EM, El-Abbadi M, Giachelli CM Am. J. Pathol., 2011;178(2):764-73. Species: Mouse Sample Type: Whole Tissue Application: IHC Paraffin-embedded Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease. Authors: Todoerti K, Lisignoli G, Storti P, Agnelli L, Novara F, Manferdini C, Codeluppi K, Colla S, Crugnola M, Abeltino M, Bolzoni M, Sgobba V, Facchini A, Lambertenghi-Deliliers G, Zuffardi O, Rizzoli V, Neri A, Giuliani N Exp. Hematol., 2010;38(2):141-53. Species: Human Sample Type: Whole Cells Application: ICC Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Authors: El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM Kidney Int., 2009;75(12):1297-307. Species: Mouse Sample Type: Whole Tissue Application: IHC Paraffin-embedded Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. Authors: Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M EMBO J., 2008;27(3):535-45. Species: Mouse Sample Type: Whole Tissue Application: IHC Paraffin-embedded Emergence of patterned stem cell differentiation within multicellular structures. Authors: Ruiz SA, Chen CS Stem Cells, 2008;26(11):2921-7. Species: Human Sample Type: Whole Cells Application: ICC The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Authors: Curran JM, Chen R, Hunt JA Biomaterials, 2006;27(27):4783-93. Species: Human Sample Type: Whole Cells Application: ICC
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human RUNX2/CBFA1 isoform 2 Lys233-Tyr418 Accession # Q13950
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	CBFA1, also called runt-related transcription factor 2 (RUNX2), is an essential transcription factor for the regulation of osteoblast differentiation (1). The CBFA1 gene potentially encodes several proteins that differ in their N-terminal sequences and transactivation capacities (2).
运输条件	Blue Ice
存放说明	4℃
参考文献	Ducy, P. et al. (1997) Cell 89:747. Xiao, Z.S. et al. (1998) Gene 214:187. Sato, M. et al. (1998) Oncogene 17:1517.

参考图片

RUNX2/CBFA1 in U2OS Human Cell Line. RUNX2/CBFA1 was detected in immersion fixed U2OS human osteosarcoma cell line using Rat Anti-Human RUNX2/CBFA1 Monoclonal Antibody (Catalog # MAB2006) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red, upper panel; Catalog # NL013) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.