| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.
Authors: Wortham B, Eppert B, Flury J, Garcia S, Donica W, Osterburg A, Joyce-Shaikh B, Cua D, Borchers M
J Immunol, 2015;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.
Authors: Charles, Julia F, Hsu, Lih-Yun, Niemi, Erene C, Weiss, Arthur, Aliprantis, Antonios, Nakamura, Mary C
J Clin Invest, 2012;122(12):4592-605.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Comparison of gene expression profiles between human and mouse monocyte subsets.
Authors: Ingersoll MA, Spanbroek R, Lottaz C
Blood, 2010;115(3):e10-9.
Species: Mouse
Sample Type: Whole Cells
Application: Flow |
| 背景 | MDL-1 is anapproximately 40 kDa transmembrane glycoprotein belonging to the C-type lectinsuperfamily (CLEC5A). MDL-1 is expressed on immature myeloid cells, monocytes,macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. Itcontains a charged lysine in the transmembrane region that enables it toassociate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses duringautoimmune arthritis and upon binding to Dengue and Japanese encephalitisviruses. The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalkregion and one C-type lectin domain. Within the ECD, mouse and human MDL-1share 67% amino acid sequence identity. In mouse, alternative splicinggenerates a short isoform with a 25 aa deletion in the stalk region. |
