Human/Rat SOX10 MAb (Clone 20B7) (25 UG)【科瑞奥博】

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Human/Rat SOX10 MAb (Clone 20B7) (25 UG)

货号： MAB2864-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB2864-SP
别名	DOM; MGC15649; PCWH; SRY (sex determining region Y)-box 10; SRY-related HMG-box gene 10; transcription factor SOX-10; WS4; WS4C; WS4mouse, human homolog of
全称	Transcription Factor SOX10
反应种属	Human/Rat
应用	Immunohistochemistry(5-25 µg/mL) Immunocytochemistry(8-25 µg/mL)
目标/特异性	Detects human and rat SOX10. Epitope-mapping experiments indicated that clone 20B7 recognizes a determinant in the first 65 amino acids, which contains sequences unique to SOX10 (1).
使用方法	Immunohistochemistry: 5-25 µg/mL Immunocytochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	6663 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Perivascular-derived stem cells with neural crest characteristics are involved in tendon repair. Authors: Xu W, Sun Y, Zhang J, Xu K, Pan L, He L, Song Y, Njunge L, Xu Z, Chiang M, Sung K, Chuong C, Yang L Stem Cells Dev, 2015;24(7):857-68. Species: Rat Sample Type: Whole Cells Application: ICC Fluorescence Modulation of lipopolysaccharide-induced neuronal response by activation of the enteric nervous system. Authors: Coquenlorge S, Duchalais E, Chevalier J, Cossais F, Rolli-Derkinderen M, Neunlist M J Neuroinflammation, 2014;11(1):202. Species: Rat Sample Type: Whole Cells Application: ICC HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Authors: Jacob C, Christen CN, Pereira JA, Somandin C, Baggiolini A, Lotscher P, Ozcelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P, Suter U Nat. Neurosci., 2011;14(4):429-36. Species: Rat Sample Type: Cell Lysates Application: WB A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Authors: Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S Stem Cells, 2007;26(1):163-72. Species: Human Sample Type: Whole Cells Application: ICC
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant rat SOX10 aa 1-118
生物活性	Human, Rat
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	SOX10 belongs to the SOX family of transcription factors which displaydiverse roles during development. In the central nervous system, SOX10is required for the terminal differentiation of oligodendrocytes andmyelination. In the peripheral nervous system, SOX10 maintainspluripotency of neural crest stem cells and suppresses neuronaldifferentiation.
运输条件	Blue Ice
存放说明	4℃
参考文献	Lo, L. et al. (2002) Development 129:1553.

参考图片

SOX10 in BG01V Human Embryonic Stem Cells. SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Mouse Anti-Human/Rat SOX10 Monoclonal Antibody (Catalog # MAB2864) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

SOX10 in Human Melanoma Tissue. SOX10 was detected in immersion fixed paraffin-embedded sections of human melanoma tissue using Mouse Anti-Human/Rat SOX10 Monoclonal Antibody (Catalog # MAB2864) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.